The 51-year-old actor contemplated committing suicide after doctors told him that he was infected with the human immunodeficiency virus - the agent of the currently-incurable disease AIDS - but he changed his mind after he saw his mother Janet.
Speaking on 'Good Morning America' on Wednesday (11.01.17), he said: "The day I was diagnosed, I immediately wanted to eat a bullet. But my mom was there, I wouldn't do that in front of her, or let her find me to clean up that mess."
But, despite the initial fear he felt after he found out he was HIV-positive in 2011, the 'Two and a Half Men' star is "so grateful" to be alive and to be able to spread awareness.
He explained: "I feel really good. I am so grateful. I feel like I'm carrying the torch for a lot of folks out there that are suffering from the same thing."
Charlie is now on a trial for a new drug that he hopes will make his battle with the incurable condition more manageable because it only requires one injection a week.
He said: "Some days are better than others, but most days are pretty f***ing cool. I'm so grateful for what was available when it happened, and even more grateful for what's available right now, when I'm, I'm in the middle of it, you know?"
Charlie has now returned to work and will next be seen in the forthcoming film 'Mad Families' and is trying to rebuild his relationship with his children Cassandra, 32, Sam, 12, Lola, 11, and seven-year-old twins Max and Bob.
He said: "It's really refreshing. You've had a terrible day ... And you come home, and your kids are like, 'Oh, my gosh. Look who's, look who's here.' "
The actor's current state is a world away from the condition he was in six years ago when he claimed he was able to do as many drugs as he wanted because he's got a "different brain, a different heart" and "tiger blood."
However, looking back on his wild antics, Charlie now thinks his erratic behaviour was down to the side effect of using too much testosterone cream.
He explained: "Dude, what the hell was that.
"Way too much testosterone cream, trying to keep the old libido up. It metabolizes into steroids. That whole odyssey was an accidental 'roid rage."