Sarri is under pressure at the Turin club, despite leading them to a ninth successive Serie A title, and his side face a battle to reach the quarter-finals of the delayed Champions League.
Juve have not won Europe's top competition for 24 years but Sarri does not fear for his job should they fail to overturn a 1-0 deficit against the French side.
He said: "I don't think my future is riding on this game.
"Thinking this way you make the club directors look like amateurs.
"I think I'm dealing with high level directors. They will decide whether to continue or to change. But it doesn't depend on a single game."
Sarri also revealed that Cristiano Ronaldo is ready to play the match, having been rested for Juve's final Serie A game last weekend.
The 61-year-old coach said: "Ronaldo is training in the right manner.
"On Wednesday he scored an excellent goal in training. He played many games in a short time, he rested a little and now he has trained with intensity and strength."
The match will only be Lyon's second fixture since March, after Ligue 1 did not resume due to the coronavirus pandemic, although boss Rudi Garcia is determined to progress to the last eight, which will be played in Lisbon.
He said: "We won't only want to defend; we will also want to score a goal. Juve have many great players, many stars. We are humble, but very ambitious - we want to qualify."