The 47-year-old promoter - who has overseen Joshua's professional career - insists the fight hasn't lost any of its lustre, even though they've both suffered defeats in recent years.
Speaking to The Ring magazine, Hearn said: "You're always going to get the naysayers who say, 'Oh, it's not quite as big'. Trust me, when these two come face to face, the world will stop.
"When these two walk into the ring in November, the front and back page of every national paper will be about this fight. It is, by far, the biggest fight in boxing. The biggest fight in the history of British boxing."
It's been widely suggested that the fight has lost a lot of its appeal because Joshua and Fury are both now near retirement.
But Hearn has rubbished that suggestion, insisting that Joshua is back at the "top of the sport" after defeating Jake Paul in Florida in December.
Hearn reflected: "AJ had more momentum in 2021. We had the Usyk fight, we signed to fight Tyson Fury. But then you look at ... you know, the Jake Paul fight last year, which wasn't the greatest fight of all time. But from a profile perspective, it really took AJ back to the top of the sport."
Hearn also concedes that Fury's profile has grown in recent years.
The promoter said: "Fury has now come on, he's a household name with his Netflix show."
Earlier this month, meanwhile, Frank Warren argued that Joshua is "vulnerable".
The veteran promoter is convinced that Fury, the former heavyweight champion, will simply have too much for Joshua in their upcoming clash.
Speaking to SecondsOut, Warren said: "He’s got that spectre and that cloud over him of what happened to him when he fought against Daniel Dubois. You know he is vulnerable if he gets caught now. Tyson will stop him.
"Did you see him fight Daniel Dubois? I was confident Dubois would do that and he did. I’m confident Tyson will do the same thing. If he catches him, he will go."