Vokes departed for international duty after netting Burnley's goal in their draw with Huddersfield Town at the weekend and will be looking to take that form onto the international stage.
After the disappointment of missing out on the 2018 World Cup, the appointment of Ryan Giggs as the new manager has put the feel good factor is back in Welsh football.
Speaking about the Manchester United legend taking charge of the national team, Vokes said: "These are exciting time for us. It's a strong squad now and the new generation of lads coming through is great to see. The Ireland game was one of the strongest performances we've put in for a long time. We've got two good games now and it's exciting to be back at the Principality Stadium playing Spain.
"We've had a great atmosphere at the Cardiff City Stadium and now we can take that momentum to the Principality Stadium."
Vokes still needs one more appearance to reach the 60-cap mark after missing out against the Republic of Ireland and Denmark last month.