Higuain did not feature as Milan claimed a 2-0 Serie A win at Genoa on Monday, with Rossoneri assistant Luigi Riccio remaining cool about the striker's absence.
Higuain, who is on loan at Milan from Juventus, is reportedly wanted at Chelsea by his ex-Napoli boss Maurizio Sarri.
"As for the transfer market we are all grown-ups, we know how to deal with these situations," Riccio said, according to Gazzetta.
"It has been in the air for a few days. But we will work with the players at our disposal."
Higuain was left out of the Milan squad for Monday's trip, with Rossoneri boss Gennaro Gattuso admitting pre-match that the speculation had disrupted preparations.
Meanwhile, Genoa could help expedite Higuain's departure to London by selling Piatek to Milan.
The clubs were reportedly set to discuss a deal for the Polish striker following Monday afternoon's match.
The deal for Higuain is a complicated one, given negotiations must involve Milan and his parent club Juventus.