The airline has confirmed a series of operational reductions between June and September, affecting both domestic and international services across Asia.
Destinations impacted include China, Japan, India, Indonesia, Singapore and Nepal, with some routes facing reduced frequencies and others suspended entirely.
Among the most significant changes is the Phuket to Singapore service, a route particularly popular with holidaymakers.
The connection will be suspended completely between 3 June and 1 August before resuming with only two weekly flights during August, down from the previous four services per week.
Thai Lion Air said the adjustments were largely driven by the aviation fallout from continued instability in the Middle East.
Fuel prices have surged since the escalation of the US-Israeli conflict involving Iran and the closure of the Strait of Hormuz, a key shipping route for global energy supplies.
Jet A-1 aviation fuel, which reportedly traded at around $80 per barrel before the conflict, has in some cases climbed beyond $240 per barrel.
With fuel typically accounting for roughly 30 per cent of airline operating costs, carriers are increasingly being forced to reduce frequencies and temporarily withdraw routes to control spending.
Medium and long-haul services have proven especially vulnerable.
Passengers travelling with Thai Lion Air have been advised to closely monitor bookings as schedules may continue to change depending on fuel prices and passenger demand.
The disruption is not limited to Asia.
European carriers are also feeling the pressure as aviation leaders warn that a prolonged conflict could disrupt supply chains, raise operating costs and delay aircraft production.
Dutch airline KLM has already extended suspensions on several Middle Eastern routes.
The Air France-KLM carrier confirmed services to and from Dubai will remain suspended until at least 2 August, while flights to Riyadh and Dammam are grounded until at least 12 July.
Indian airlines are also grappling with rising costs.
Major carriers including Air India, IndiGo and SpiceJet have reportedly urged state-run oil companies to delay planned increases to domestic aviation fuel prices as the conflict continues to squeeze airline finances.
According to reports, Indian fuel suppliers have been considering raising aviation turbine fuel prices by as much as 25 per cent from June.
The latest cuts underline mounting concern across the travel sector that the Middle East conflict could continue to reshape airline schedules and increase pressure on fares throughout the peak holiday season.
