The iconic road, which runs across the United States from Santa Monica to Chicago, and passes through the likes of California, Arizona, New Mexico, Texas, Oklahoma, Kansas, Missouri and Illinois has been named as the most iconic road trip for British travellers looking to capture the perfect Instagram picture.
And taking a drive through the Grand Canyon parks was second on the list, followed by Route 101 - also known as the Pacific Coast Highway - placed third.
The route from Australia's West Coast Perth to Broome and New Zealand's South Island Circuit rounded off the top five, with Snowdonia in Wales squeezing into tenth place.
Temerity Vinson, senior director of international marketing at Hertz said: "The survey results clearly show how much adventurers love the USA for a road trip. The influence of social media has had a huge impact on destinations of choice, bringing increased awareness of less well-known areas, as well as ensuring that gems such as the Route 66 are still as popular as ever. Hertz is always dedicated to finding new ways to help our customers plan their dream trip. Our USA Road Trip Planner can help our customers experience a different culture, discover new cuisines or visit famous landmarks."