The British number one progressed at the Citi Open with a hard-fought victory over Camila Osorio but was left in agony by the blisters in very hot conditions.
Speaking after the match, Raducanu said: "I think I died about three times in that match and I came back - honestly, I don't know how.
"Camila is such a battler. I was working so hard for every single point. When she comes back, the dynamic of the match changes a bit, so I am just really pleased to have got through that one."
The star explained the effects that the blisters had as the match went on.
She said: "At the beginning of the match I was alright, but then throughout the match my skin was just ripping off - it was pretty raw and open."
Raducanu is gearing up for the defence of her US Open crown and revealed that she isn't contemplating the rankings drop she could suffer if she fails to perform at Flushing Meadows.
The sports star said: "I think that no matter what I said, I probably did have, you know, certain expectations of myself that were probably a bit twisted. And now I genuinely just accept it.
"Okay, it's not going to be pretty necessarily or easy, but I'm like 100 per okay for starting over, to be honest.
"Like if my ranking plummets to like 1000 or whatever, then I don't care."