The bout pits The Falsh, 27, against reigning champion El Azteca, 30, after both men agreed terms late last year.
Speaking ahead of the defence, Barrios said in a statement: “Becoming WBC welterweight world champion was more than a moment. It was a promise to my family, my city, and everyone who believed in the grind when no one was watching.
“San Antonio built me, and every sacrifice I’ve made comes with me into that ring. This is my division, my time, and I’m ready to show the world why the WBC title stays right here.”
Barrios was elevated from interim to full WBC champion in June 2024 and has since retained the belt twice, albeit in controversial circumstances.
He drew with Abel Ramos, 34, in November 2024 before reaching a majority draw with Manny Pacquiao, 47, in their July 2025 clash.
For Garcia, the fight represents a chance at redemption, as he has not recorded a victory since stopping Oscar Duarte, 29, in December 2023 and was last seen losing on points to Rolly Romero, 30, in May 2025 for the WBA ‘regular’ title.
That bout marked his return from a one-year suspension after testing positive for a banned substance following his victory over 27-year-old Devin Haney - which was subsequently overturned and the fight deemed a no contest.
Despite recent setbacks, Garcia is adamant this is his moment.
He said: “I will be world champion on February 21.”
The matchup also carries wider implications for the welterweight picture.
Conor Benn, 29, has been installed as the mandatory challenger for the WBC title and is targeting the winner in 2026.
His promoter Eddie Hearn recently said he believes a Garcia victory would set up one of boxing’s biggest commercial fights.
Speaking to Matchroom Boxing, Hearn said: “Ryan Garcia against Conor Benn – arguably the biggest fight in boxing. We would take 15,000 [fans] to Las Vegas for that fight; Conor would sell out a stadium with Ryan.”
Hearn added that Benn is “obsessed” with the WBC belt and will not wait around unless a guaranteed title shot is secured.