Pochettino confirmed he will rest Lloris for the game and there may be plenty of other changes after he insisted that top stars like the France goalkeeper are not "machines".
"It's true that we'll play Michel Vorm," said Pochettino. "Hugo is not a machine, he's one of the best but he's not a machine. It is a very good opportunity for Michel, he deserves to play.
"Players like Lloris, they are not machines. And it is very tough to go from international matches, to the Premier League, to the Champions League and back to the Premier League, without any breaks.
"So we will rotate and we will rotate in the next few games too, because it's important that the whole squad feel they are important, have the chance to play and show their quality."