Ozil has missed Arsenal's last two matches and was left out of Germany's World Cup qualifiers over the international break but has now recovered from a knee injury and could be involved at Vicarage Road.
Wenger says the forward faces a fight to reclaim a starting spot, but he stressed he views Ozil as one of the world's best when on top form.
"Of course he is important. But I have many players - we spoke about Jack [Wilshere], we spoke about [Alex] Iwobi," Wenger said.
"They are all players who play in this similar position and it is very interesting because it gives me a lot of opportunities to keep them all focused and refreshed.
"People go quickly to conclusions. Last year we played the last 11 games and won 10. We beat Man City in the FA Cup semi-final and Chelsea in the final and he played as well. You can always find the example. But it's true that we have done well recently.
"We live in the world where people have opinions and sometimes they are right and sometimes they are not always proven right on the longer period. You need players who have quality and Ozil is one of the best players in the world."
Ozil is out of contract at the end of the season but Wenger remains hopeful he will agree an extension, although he recently admitted the club could decide to sell the German in January if he does not agree fresh terms