Centre-half Gary Cahill is a doubt after limping off with a hamstring strain last weekend against Leicester City and Ross Barkley is ineligible due to not registering in time.
With the league seemingly out of reach, Antonio Conte now has to concentrate on the cups but admits he will still rotate his side.
Conte said: "We want to try to win and try to find the best way to win. For sure, we are making many rotations like in the first game. But, at the same time, we want to go into the next round.
"For sure, to have many games, we must be proud because it means that, in every competition, we are going forward. But, at the same time, you arrive at the end of February and March risking to be tired."