Ireland coach Joe Schmidt is without the British and Irish Lions trio for the Dublin clash after they were all injured in his side's 56-19 win over Italy on February 10.
'There are obviously forced changes, but they're at home so it's going to be tough whatever Irish side we face,' said Jones.
Jones, who played alongside all three injured players on the 2017 Lions tour, believes they will be a loss, but expects replacements Andrew Porter, James Ryan and Chris Farrell to be inspired by the occasion.
'They're quality players with British and Irish Lions experience and players of that experience are a loss,' said Jones.
'Whoever fills the void has a point to prove after missing out initially and will want to take their opportunity.
'I've heard a lot about Porter from Tadhg Furlong on tour. He's a big, strong boy. James Ryan has had a few appearances for Leinster and Ireland and then there's Stockdale on the wing and Farrell in the centre.
'They've had a few opportunities and I'm sure they'll be looking to get those again in the green jersey.'