England are currently making their preparations to head to the southern hemisphere for a three-Test series against the Springboks, starting in Johannesburg on June 9.
Eddie Jones' men have not played since the Six Nations, giving them plenty of time to digest what was their worst performance in the championships since 1987 as they finished fifth in the table.
Having won the previous two Six Nations titles, including the Grand Slam in 2016, this year's result came as a major surprise to England fans.
Despite having performed so well under Jones since he took charge in 2016, Borthwick says the time has come for the team to 'break the mould' as they seek to bounce back with a first-ever Test series win in South Africa.
The forwards coach told the Independent: "In a lot of ways we got some pretty good feedback from the Six Nations about what we need to change and what we need to work on.
"That has given us a help, given us great direction about what we need to do to face the challenge of this summer.
"We have got to do things differently, we have got to change what we have done previously and we have got to do things differently to what England teams have done before.
"We have never won a Test series in South Africa. If we do things the same as we have done before we will probably end up with the same results - and we have got to change."