The partnership between the two organisations will see industry leading tutors and alumni from the institution hosting a bespoke curriculum of free workshops and events hosting at the tech giant's flagship London store.
Classes will be held on sustainability, innovation, digital fashion design and entrepreneurship on September 14 and 15.
Meanwhile, fans will also be able to create and print their own free tote bag using Microsoft surface devices, and they will get to customise one of four prints designed by LCF textile graduates.
Matthew Drinkwater, Head of Fashion Innovation Agency at LCF, said: "We want to inspire people to think differently about the fashion industry.
"By creating a unique workshop programme, Microsoft Store and London College of Fashion, UAL is bringing people closer to the fashion industry and showcasing how cutting-edge technology such as Microsoft HoloLens can disrupt the industry as we know it.
"It's an exciting opportunity to experience the future of fashion on our doorstep."
And senior store manager John Carter added: "Through unique retail experiences, Microsoft Store aims to bring people closer to a range of technologies, and the Microsoft Store x London College of Fashion Curriculum is just one example of how the flagship is the best place to experience all that's possible with Microsoft."