A £300 million bid from an investment group financed by the Saudi Public Investment Fund has been accepted by current owner Mike Ashley but it is still awaiting approval from the Premier League, even though documents for the deal were submitted almost three months ago.
Speaking after Newcastle's FA Cup quarter-final loss to Manchester City, Bruce said: "For everybody, we need a bit of clarity.
"If I'm led to believe it's the Premier League that is holding these negotiations, then they have got to come and make a decision sooner or later because it's not healthy for anybody."
The 59-year-old coach added that the speculation is "not healthy for anybody" and the matter needs to be settled.
Bruce said: "It is not healthy for anybody.
"As I have said for me personally, and we have another game on Wednesday now (at Bournemouth) and we have a wonderful opportunity.
"We can't use that (the takeover) as an excuse but we need a bit of clarity and get it put to bed one way or another."
Newcastle were beaten at St James' Park by a Kevin de Bruyne penalty and a Raheem Sterling strike and Bruce felt his team needed to be more aggressive against Pep Guardiola's side.
He remarked: "We made it a bit of a cup tie but for long periods it didn't feel like that. I was a lot more pleased with us in the second half.
"You cannot make the type of mistake we did for the penalty. We have given a poor penalty away. We had to be more aggressive towards them."