The English top-flight differs from other European leagues as clubs are only allowed to make the standard three changes despite the fixture congestion caused by the delayed start to the season and Guardiola and Klopp are demanding a rule change as Liverpool defender Trent Alexander-Arnold was injured in the heavyweight clash with Manchester City.
Asked about what he discussed with Klopp at the final whistle, Guardiola told BBC Sport: "We talked about five substitutions. If people want to give microphones so we can give our opinions... English player, right-back is injured.
"There are many guys with many, many cases. Around the world five subs are key, but here it's totally the opposite. We've talked about this many times."
The Manchester City coach added: "Trent Alexander-Arnold, international English player, now injured.
"Here we believe we are more special, we don't protect the players, so that is why it is a disaster.
"This calendar came from a year before and I will demand for players to come back otherwise it will be difficult to maintain it."
Gabriel Jesus secured a point for City in the 1-1 draw with the Reds and Guardiola was pleased with his team's reaction to going behind - even though Kevin de Bruyne missed a penalty that could have secured the win.
He said: "It was a tight game. We struggled in the first minutes because they had four players up front.
"[Sadio] Mane and Salah were playing between the lines then we adjusted after and had more control.
"The way they played and the way we behaved in response was incredible. I'm so proud of my players.
"The difference today was they got a penalty and we missed a penalty."