The Filipino fighter hasn't competed in the ring since 2019 and revealed that he is determined to take on the UFC star in a future bout.
Pacquiao admits that he finds a clash with 'The Notorious' more appealing than fights against either Errol Spence Jr and Terence Crawford.
He said: "They're (Spence and Crawford) my options, but right now I want to experience fighting a mixed martial artist."
Pacquiao also pledged to donate much of his fight purse to those who have been affected by the coronavirus crisis in the Philippines.
McGregor is set to return to UFC later this month with a rematch against Dustin Poirier and his manager Audi Attar believe a fight between the pair is "inevitable" this year.
Attar, who represents both men, said: "I definitely believe it's inevitable for 2021.
"Both fighters want it, that's the key.
"You can't make something happen or orchestrate it or choreograph it - which is the buzzword of this interview - you can't fake that.
"If one side wants it and the other doesn't, it's not going to happen. But when both fighters want that fight to happen, why wouldn't it happen?
"If the fans want to see it - that almost guarantees that it's going to happen, right? As there's enough interest to develop something there."