The two men, who were rivals in the ring have worked together for the last three years during which Chisora’s won three fights, including a stoppage of David Price.
But he was also knocked out by Dillian Whyte and lost on points to Oleksandr Usyk and Joseph Parker.
And although he’ll no longer be working with Chisora, Haye will still be keeping a keen eye on the 37-year-old heavyweight's career.
He said: "It's been an action-packed couple of years, getting Derek back in the mix of the heavyweight division, taking him from 'Del Boy' to 'WAR' mode.
"When we announced our unlikely partnership we pledged to give fight fans the big nights of heavyweight clashes they have called out for and that I believe we have achieved.
"Whilst I will no longer be managing Derek, I will naturally continue to follow and support his career with great interest.
"The UK remains at the epicentre of the heavyweight division and Derek stands ready to go toe to toe with them all.
"2021 is looking very exciting for him with a number of options available."
And Chisora believes his record over the last two and and a half years shows he made the right decision in employing Haye as his manager.
He said: "Everyone close to me thought I was crazy when I told them I wanted David to manage me, but in the last two and a half years my performances in the ring have spoken for themselves.
"Giving fight fans the battles they wanted to see even when COVID put a handbrake on everything.
“I may have been robbed against both Usyk and Parker but I have developed as a fighter.
“2021 is looking very interesting, I am back in camp, ready to go this autumn.
“It's time for WAR.
"I would like to thank David for his support (at times patience...) and guidance during our time working together."