The 23-year-old winger scored in the Gunners' 5-0 win over Leeds on Saturday (23.08.25) but wasn't able to finish the match.
As reported by Sky Sports News, Saka is set to miss Mikel Arteta's team's clash with Liverpool this weekend due to a hamstring issue.
He will also be forced to miss England's upcoming World Cup qualifiers against Andorra and Serbia on September 6 and 9.
However, it's said the injury shouldn't be a long-term problem, even if he could be on the shelf for up to four weeks.
Similarly, Gunners captain Martin Odegaard is also a doubt for the match at Anfield after hurting his right shoulder.
The club are optimistic that their leader won't be out for long.
Saka was on the sidelines for three and a half months last season after undergoing surgery on his right hamstring.
This time though, the issue is on his left leg, rather than a recurring problem.
Arsenal forward Kai Havertz has already suffered an issue with his knee during the new campaign, but manager Arteta has a wealth of new attacking options.
Former Crystal Palace star Eberechi Eze could make his debut for the Gunners against Liverpool after making the move across London.
Meanwhile, the club also signed Viktor Gyokeres and Noni Madueke, bolstering a lineup already featuring Gabriel Martinelli and Leandro Trossard.
Gabriel Jesus is still recovering from an ACL injury, but academy graduates Max Dowman and Ethan Nwaneri are providing added depth to the squad.
The 2025/26 Premier League campaign has started well for Arsenal, who escaped with a 1-0 win against Manchester United on the opening day before trouncing Leeds, leaving them top of the table on goal difference after two games.