The pair grew up together, playing through the ranks at Saracens after Farrell joined as a 14-year-old and have gone on to earn both domestic and European honours for the club.
Last summer saw their partnership further extended as they started all three Tests for the British & Irish Lions during the drawn series in New Zealand.
Both are expected to be involved on Saturday as the Red Rose aim to outwit the Auld Enemy at Murrayfield.
While he mainly plays fly-half at Saracens, Farrell has featured at inside-centre for England in recent years and hooker George believes his ability to adapt is what makes him such a special player.
"His maturity is the main thing that he's worked on," George said.
"He'd say himself that he was pretty raw when he first started international rugby but the way he's developed as a leader and as a player -- he's showing that he's one of the best players in the world. We're very lucky to have him for club and country.
"He's constantly evolving his game. He himself says that he's a 10 but when he plays at 12 he picks incredible lines. It's another string to his bow. He showed against Wales, lots of line-breaks and you don't always see a 10 doing that."