The England Under-21 defender has returned to Villa Park for the duration of the 2018/19 campaign.
He made five appearances for the Sky Bet Championship club last season when Steve Bruce's side were defeated in the play-off final.
'It's great to be back. This is a big, big club and to represent it again is a big honour for me,' the 20-year-old told avfc.co.uk.
'It made perfect sense for me to return for the season ahead. I know my way around the place now and owe a lot to the great people who've really looked after me.
'It was a no-brainer and now the ambition remains the same as last season - to reach the Premier League.
'I believe the squad we have here are more than capable of achieving it and playing at that level.'
Tuanzebe has played five times in the Premier League for United and also made a substitute appearance in the Champions League.