The north London outfit spent last term playing their home games at Wembley as work on their new stadium - built on the site of their old White Hart Lane ground - took place.
Spurs were set to step out at the new 62,062-seat arena on September 15 to face Liverpool, however, that match will now take place at Wembley.
Their following home fixture, which comes against newly promoted Cardiff on October 6, has also been switched to the national stadium.
Tottenham's clash with Premier League champions Manchester City on October 28 is currently "to be confirmed".
A club statement read: "Recent testing and commissioning has now shown issues with the critical safety systems.
"We are reviewing the situation and planned timetable to rectify and re-test, after which we shall be in a better position to outline a revised timetable.
"The delays created by these difficulties mean that we can no longer hold the necessary test events on 27 August and 1 September. These will need to be rescheduled to take place ahead of any first official match at the new stadium in order to achieve the safety licence."
Tottenham chairman Daniel Levy added: "We know this will be disappointing for all our season tickets holders, premium members and our fans worldwide.
"At the start of the project we asked for your support during what we knew would be a complex and challenging build and now we ask for your continued patience and forbearance."