The pair have only recently returned to action and the United interim boss is keen for them to get game time, as Solskjaer seeks a fifth straight win during his time in the Old Trafford hot-seat.
The Norwegian will be without injured pair Marcos Rojo and Chris Smalling, while Marouane Fellaini will have a late fitness test to decided whether he can play a part in the third-round tie.
Paul Pogba is expected to be left on the sidelines after suffering a knock against Newcastle, but Fred and Diogo Dalot are being tipped to start against the Royals, while Sergio Romero is expected to replace David de Gea between the posts.
Reading head to Manchester having slipped into the Championship relegation zone after failing to win any of their last 10 matches and have lost on their last three visits to Old Trafford - including a 4-0 FA Cup loss last year.
Republic of Ireland defender John O'Shea, who spent more than 10 years as a player at Old Trafford, is hoping to start against his former club.