The final weekend of this year's Six Nations sees leaders Wales host Ireland before England face the Scots, meaning England will know if it is possible for them to claim the crown on 'Super Saturday'.
England are currently one point behind Wales, with Ireland a further point back.
But any what-ifs and hopes from the England camp are not on the agenda this week for Eddie Jones' side, as number eight Vunipola explained.
"It's important we focus on the job in hand and they (Wales) have their own job to do," the Saracens forward told Sky Sports in an interview. "We have to leave all the other pieces we can't control over to those that can - what we can do is concentrate on turning up on Saturday and how we play.
"I'd be lying if I said I was happy that it wasn't in our own hands but it's like anything in life - whatever happens before our game will happen.
"We just have to put our best foot forward at Twickenham."
Scotland are currently injury hit and come into this game with a dismal record at Twickenham having not won there since March 1983.
However, that poor away form is not something Vunipola is reading into.
"I think Scotland have been maybe five or 10 percent off winning all four of their games this year," he added. "It would be amiss if we underestimated their threat - history can be misleading and records are there to be broken.
"It's important we keep our feet on the ground and make sure we don't give them what they want. We need to make sure we are on our game and not get involved in little scuffles.
"Everything else is irrelevant and the best way to hurt any team is to hurt them on the scoreboard."