The Reds are looking to use the anguish of finishing second by one point to champions Manchester City last season as motivation, as they go in search of their first Premier League title.
Liverpool's campaign starts with the arrival of a Norwich side who secured the Championship title last season, and who will be looking to cause a real upset under the floodlights at Anfield.
Klopp has been forced to do without star forward Mane through pre-season after the Senegal international took part in the Africa Cup of Nations.
However, Mane could reunite with strike partners Mohamed Salah and Roberto Firmino for the arrival of the Canaries.
Liverpool will also be boosted by the news James Milner has recovered from a muscle strain and is available for Friday's game.
The utility star missed the Community Shield defeat at the hands of City although the veteran has recovered and could play a role for Klopp's side.
Liverpool will be without Nathaniel Clyne after the full-back was ruled out for six months with cruciate ligament damage.
As for Norwich, manager Daniel Farke has a handful of injuries to deal with ahead of his first game in charge in the Premier League.
Central defenders Timm Klose and Christoph Zimmermann are both sidelined, while midfielders Alex Tettey and Louis Thompson are also struggling with injuries.
Summer signings Josip Drmic and Patrick Roberts could be given the nod for the opener, which Farke knows will be a massive test for his side.
"I had a little smile when I saw our first game is against Liverpool," he said.
"For me, they might be the best team in the world right now.
"Our lack of Premier League experience could be a positive. Our naivety could be a good thing.
"I want my players to go out there and think about why they first started playing football. I want them to be brave and enjoy playing."