The South Korean firm released the first ever high definition player of its kind 13 years ago, but they have now confirmed they are no longer going to sell the hardware in the US.
Samsung follows in the footsteps of Oppo who quit the market last April.
The last Blu-ray was released in 2017, and it was reported that a new model was in the works for a release in 2018, but that appeared to be axed.
Blu-ray is the go-to hardware for watching 1080p and later 4k media.
Meanwhile, Samsung is busy preparing for the launch of their first foldable smartphone.
A live streamed event to launch the revolutionary product is schedule for Wednesday (20.02.19) from 7pm GMT.
Plus there was a billboard spotted at the Place de la Concorde in Paris, France, which reads: "The future unfolds - February 20" in the Korean alphabet.
The innovative device - which is already known to be launching in 2019 - will act as both a tablet and phone, with two displays depending on which format it is being used in.
As previously reported by CNET, members of the company's system software group explained that there will be a 7.3-inch interior display used when its in tablet mode, but when closed up it will act as a smartphone with a 4.5 exterior screen.
Justin Denison, the tech giant's senior vice president of mobile marketing, unveiled the device and revealed it uses a new technology called Infinity Flex Display.
He said: "The Infinity Flex Display represents an entirely new mobile platform.
"We've been living in a world where the size of your screen can only be as large as the device itself. We've added a new dimension to help you browse, watch and multitask like never before."
Meanwile, CSS Insights analyst Ben Wood offered some speculation on whether the new device could become a popular one with customers.
He suggested: "The success or failure of Samsung's first folding phone will depend on how well Samsung has been able to button up the device.
"If it's a slick, attractively designed device it will be a magnet for gadget lovers. If it is bulky and hard to use it will be a tougher sell."