The video streaming giant has decided to take action against channels on its site that push anti-vaccination conspiracy theories, by making sure they no longer receive money from adverts on their videos.
Over the weekend, YouTube stopped serving ads to several popular channels which promote such views, following protests from firms who discovered their adverts were running alongside the controversial videos.
In a statement, YouTube said: "Any misinformation on medical topics is especially concerning."
Alongside the decision to remove adverts from the videos, the company is also trying to make "more authoritative content" on the benefits of vaccinations easier to find, and is stopping anti-vaccination videos from appearing in users' recommended lists.
The company is also planning to create "information panels" on pages that listed sources where people can fact-check information for themselves.
They said: "Like many algorithmic changes, these efforts will be gradual and will get more and more accurate over time."
YouTube's decision is believed to have been fuelled by complaints from large advertisers who did not want their content playing alongside videos promoting anti-vaccine views, with some companies pulling their adverts from the site completely until action was taking.
The advertisers have been looking closely at where their adverts were appearing, after reports surfaced last week about child sex predators posting inappropriate comments on many videos featuring children.
Hasbro, Nestle, AT&T, Kellogg, Epic Games and others pulled ads following the report.