The social media site was down for users across major parts of the world including the US and the UK, with people reporting they were unable to access the platform on both web browsers and mobile devices.
The site began experiencing major issues at 2:46pm EST, with problems being reported from users attempting to access Twitter through its website, iPhone or iPad app and via Android devices, according to DownDetector.com, a site that monitors outages on social media.
Twitter acknowledged the platform was experiencing difficulties and listed the status as "investigating", as well as noting a service disruption was causing the seemingly global issue.
In a statement at the time, they said: "We are currently investigating issues people are having accessing Twitter. We will keep you updated on what's happening."
An hour later, the site was up and running again, and Twitter delivered a second statement to say the problems had been caused by an "internal configuration change".
They added: "[The outage was caused by] an internal configuration change, which we're now fixing. Some people may be able to access Twitter again and we're working to make sure Twitter is available to everyone as quickly as possible."
It comes after Facebook encountered a glitch last week, which left people unable to upload or view photos, videos and other files.
The bug affected Facebook's Messenger app, as well as Facebook-owned apps Instagram and WhatsApp, and was accidentally "triggered" during "routine maintenance".