The 30-year-old gaming fanatic - whose real name is Felix Arvid Ulf Kjellberg) - found fame on the video sharing platform with clips of him playing titles such as 'Minecraft' having amassed more than 102 million subscribers and 24 billion views.
However, he has announced he is taking a break from YouTube because he is "very tired".
On his decision to step back from his PewsNews channel, he said in a statement: "I am taking a break from YouTube next year. I wanted to say it in advance because I made up my mind.
"I'm tired. I'm feeling very tired.
"I don't know if you can tell.
"Just so you know, early next year I'll be a way for a little while. "I'll explain that later but I wanted to give a heads up."
The Swedish YouTuber hinted in August that he was contemplating some time off.
He said: "I do think it would be good for me to take a break at some point. It would be nice to not have YouTube in my brain for the first time in 10 years."
PewDiePie announced that he and his long-term girlfriend had got married that month.
Felix tied the knot with Marzia Bisognin, who he first started dating in 2011.
He gushed that he is "the happiest [he] can be" now that he's married to his "amazing" partner.
Pewdiepie wrote on Twitter: "We are married!!! I'm the happiest I can be...I'm so lucky to share my life with this amazing woman. (sic)"