The social networking platform took the action against pages and accounts in Central Europe, Ukraine and other parts of Eastern European, and in a blog post, Facebook explained that it was designed to curb the influence of groups that "manipulate people".
Nathaniel Gleicher, head of cyber-security policy at Facebook, said: "We're taking down these pages and accounts based on their behaviour, not the content they post.
"In these cases, the people behind this activity co-ordinated with one another and used fake accounts to misrepresent themselves, and that was the basis for our action."
He added that Facebook faces an ongoing challenge amid the rise of fake news.
He said in a blog post: "The people responsible are determined and well-funded. We constantly have to improve to stay ahead."
Meanwhile, Facebook recently announced that it is investing $300 million in local news.
The social media giant - co-founded by Mark Zuckerberg - is vowing to help out outlets with news programmes, partnerships and initiatives.
Campbell Brown, Facebook's head of global news partnerships, said: "The industry is going through a massive transition that has been underway for a long time.
"None of us have quite figured out ultimately what the future of journalism is going to look like but we want to be part of helping find a solution."